Diffuse changes in the liver are most often seen in viral hepatitis, as well as schistosomal cirrhosis causing recurrent fibrosis, inflammatory irritation, and infection in the liver in the form of grid-like changes. Imaging suggests diffuse changes in the liver, which in the long term can lead to cirrhosis, ascites, and even liver cancer. In normal life, the increasing incidence of fatty liver also causes diffuse liver changes, and structural changes in the liver can usually be alleviated or reversed by weight loss and exercise. Nowadays, diffuse liver changes can also be seen in malignant tumors, whether primary liver cancer or secondary liver cancer. In secondary hepatocellular carcinoma, the primary site is mostly located in the stomach and intestines, which can cause multiple occupancies in the liver, suggesting a bull’s eye sign on imaging. Some primary hepatocellular carcinomas are multiple and advanced, and these structural changes require multiple tests to determine and appropriate treatment.