The treatment of leg and knee pain should be targeted according to the cause of the disease, the cause of which mainly includes strain diseases, sports and trauma, degenerative diseases, etc. The treatment includes general treatment, physical therapy, drug therapy, surgical treatment and so on. 1. Strain-related diseases: long-term exertion, cold, etc., can cause chronic injury to the muscles and fascia of the legs and knees, resulting in chronic aseptic inflammation due to strain and painful symptoms. In this case, the pain can be relieved by rest and warmth, or can be treated with acupuncture, massage, hot compresses and other physiotherapy. 2. Diseases caused by sports and trauma: such as ligament and meniscus injuries, leg pain and knee pain can occur, mild injuries, non-steroidal anti-inflammatory drugs can be used, such as loxoprofen, celecoxib and so on, but also localized hot compresses and other physiotherapy. When the injury is more serious or the conservative treatment is ineffective, it is necessary to consider surgical treatment to rebuild the ligaments and repair the meniscus. 3. Degenerative diseases: such as osteoarthritis, in the early stage, you can wear knee pads, or with local hot compresses, massage, baking and other physiotherapy, when the pain is obvious, you can take nimesulide, diclofenac sodium and other non-steroidal anti-inflammatory drugs, but also with aminoglucosamine sulfate and other cartilage-protecting drugs, intra-articular injection of sodium vitrate can also be used. In severe cases, surgical treatment needs to be considered. The above drugs need to be used under the guidance of a doctor. When leg pain and knee pain continue to be unrelieved after rest, you should consult a doctor to clarify the cause of the disease and receive targeted treatment.