Most commonly seen in elderly patients, if the low pressure is low and high pressure is high, consider that the patient may be systolic hypertension, but also means that the patient’s pulse pressure difference is relatively large. The more common cause of this situation, mainly atherosclerosis, for such patients in the lowering of blood pressure at the same time, pay attention not to lower the blood pressure too low. If lowered too low, but will affect the perfusion of various organs, inducing the occurrence of malignant events. In the process of taking medication to regularly monitor blood pressure, but also combined with lipid anti-atherosclerosis and other drugs, such as the recommendation that patients should take long-term, aspirin, is clopidogrel. At the same time to take, like statin lipid-lowering drugs, representative drugs have atorvastatin, resuvastatin and so on. It is recommended that patients should also improve the intervention from the lifestyle, such as to pay attention to smoking cessation, alcohol cessation, low-salt, low-fat diet, exercise and weight loss, can help to slow down the progression of atherosclerosis, which can reduce the phenomenon of increased pulse pressure difference.