With the use of topical application of vitamin A cream, it is usually possible to experience peeling of the skin. Since retinoic acid cream, which is a derivative of vitamin A, has a certain antiproliferative and exfoliating effect on the skin’s cuticle. Therefore, when applied topically, there may be a certain exfoliation of the stratum corneum or dissolution of the stratum corneum, so that a certain peeling of the epidermis may be seen from the appearance, which is the symptom of peeling. Therefore, this is also the most common symptom formed after the use of vitamin A cream. If there is flushing on the face and peeling at the same time, promptly stop using vitamin A cream.