It is safer to drink alcohol 48 hours after taking amoxicillin. Amoxicillin is a penicillin drug, which can easily lead to allergy, and if you drink alcohol, it is easy to aggravate the allergy or lead to allergy. The half-life of amoxicillin is relatively short. Generally speaking, after 48 hours, the amoxicillin in the body can be metabolized cleanly, and the effect of drinking alcohol at this time is relatively small. However, it is better not to drink alcohol in general, because the damage to the human body is relatively large. Drinking alcohol can easily lead to damage to the gastric mucosa, causing acute gastritis or gastric bleeding. Alcohol has certain damage to liver function and kidney function, especially to liver function, so it is better not to drink. If you need to take anti-inflammatory drugs during a cold or sore throat, it is best to wait a week after the symptoms have fully recovered before drinking alcohol.