The pain in the fossa of the heart should be based on the cause of the medicine prescribed by the doctor, the pain caused by coronary heart disease can be prescribed to take vasodilator drugs, the pain caused by peptic ulcer can be prescribed to take proton pump inhibitors. 1. Heart disease: if the symptoms of pain in the fossa of the heart occur during exertion, exercise, emotional excitement, the pain is constrictive, oppressive, more intense in nature, and can be relieved after resting, it is necessary to highly suspect that the pain in the fossa of the heart is related to coronary artery disease. Doctors will choose vasodilators, anti-angina drugs, anti-platelet aggregation and other drugs according to the patient’s symptoms. 2. Digestive tract diseases: if the pain in the fossa of the heart is related to diet, hunger and other factors, the pain is often burning, and accompanied by nausea, bloating, belching and other digestive symptoms, we need to highly suspect that the pain in the fossa of the heart is related to gastroesophageal reflux disease, peptic ulcer and other digestive tract diseases. Doctors will choose proton pump inhibitors, gastric mucosal protectants, bactericides and other drugs according to the patient’s condition. There are many causes of pain in the heart fossa, the patient can not blindly self-medication according to the symptoms, should consult a doctor in a timely manner, a clear diagnosis and follow the doctor’s instructions to use medication.