The hand numbness to wake up in the middle of the night, may be related to the arm for a long time pressure, may also be due to carpal tunnel syndrome, cervical spondylosis and other reasons. 1. arm long time pressure: in the process of sleeping, if the arm long time pressure, resulting in arm part of the blood circulation obstacles, resulting in local nerve nutrition dysfunction, will cause the middle of the night hand numb to wake up symptoms. 2. Carpal tunnel syndrome: the disease is a nerve compression disease, can lead to the median nerve compression, and sleep blood vessels are often in a state of expansion, resulting in an increase in the volume of the wrist, resulting in a significant increase in the nerve compression, which may aggravate the symptoms of numbness, which may cause numbness in the middle of the night to wake up symptoms. 3. Cervical spondylosis: especially the existence of cervical spine osteophytes or cervical disc herniation patients, easy to sleep because of improper posture leading to local nerve root compression, resulting in compression of the nerve sensory impairment, may cause hand numbness in the middle of the night to wake up, can be accompanied by neck and shoulder pain, numbness of the upper limbs and other symptoms. Hand numbness to wake up in the middle of the night, may also be caused by other reasons, if the symptoms persist, should seek medical attention as soon as possible, after diagnosis of the cause, by the doctor’s guidance for treatment.