Normal insulin c-peptide and elevated blood glucose means that there is no lack of insulin in the body, but that there is a problem with the insulin on its way to work, such as insulin resistance, which is often seen in patients with type 2 diabetes. Fatty liver and obesity are the more common causes of insulin resistance, in addition, insulin resistance may also occur when there are special diseases or affected by drug effects. 1. Fatty liver and obesity: Fatty liver and obesity will cause glucose metabolism disorders in the body, which may lead to elevated blood glucose. For patients with obesity and fatty liver, they can carry out weight loss and fat loss, so as to improve insulin sensitivity. 2. Special diseases: such as Cushing’s syndrome patients or hyperthyroidism patients, so these patients have high levels of glucocorticoids or thyroid hormones, antagonism of insulin, so blood glucose will increase, but the level of insulin c-peptide can be normal. 3. Drug effect: If the use of glucocorticoids antagonizes insulin, blood glucose increases, but the level of insulin c-peptide is normal. At this time, blood glucose will gradually decrease after stopping the drug, if it is impossible to stop the drug, oral hypoglycemic drugs should be taken at the same time, such as metformin, insulin, etc., in order to maintain normal blood glucose. If insulin c-peptide is found to be normal and blood glucose is high, treatment should be carried out under the guidance of specialists.