Oral granulation may be caused by a variety of reasons, such as benign oral granulomatous hyperplasia, thrush, oral warts, oral tumors, etc. It can be treated by oral antibiotics, antifungal, interferon injection, laser, surgery, and so on. 1. Benign granulomatous hyperplasia of the oral cavity: repeated chewing or wisdom teeth, dental calculus, oral mucosa caused by abrasion, mucosal hyperplasia, manifested as symptoms of oral granulomatous hyperplasia. Causes should be removed, if accompanied by pain, etc., but also oral amoxicillin, cefaclor and other drugs for treatment. 2. Thrush: caused by Candida infection, manifested as oral granulation, palate, tongue surface and other parts of the white patches. It can be treated with antifungal drugs under the guidance of professional doctors, such as mycobacteria, fluconazole and so on. 3. Oral acromegaly: It will also show up as the symptom of long granulation in the oral cavity. It can be treated with fluorouracil ointment, intradermal injection of interferon, or cryotherapy or laser treatment. 4. Oral tumor: it may be caused by lipoma, hemangioma, oral cancer, adenoid cystic carcinoma and other diseases, which need to be examined to clarify the nature of the tumor. If the tumor is in early stage, surgery can be carried out, and according to the situation, whether chemotherapy and radiotherapy should be carried out should be considered. It is recommended that patients go to the hospital for consultation, to clarify the cause of the disease and to carry out targeted treatment, and the specific medication should be in accordance with the doctor’s prescription.