After staying up all night with swelling and pain in the eyes, patients can rest, hot compresses on the eyes or follow the doctor’s instructions to use medication to alleviate the discomfort. 1. Rest: rest can effectively relieve eye swelling and pain caused by staying up all night, patients need to try to ensure adequate sleep, sleep state muscles will be in a better state of rest, so that the symptoms of swelling and pain in the eyes gradually ease. 2. Hot compresses: patients can also use hot towels to apply hot compresses to the eye area, which can help promote blood circulation around the eyes. When applying hot compresses, you can also apply gentle pressure on the eyes to accelerate the blood flow, thus relieving the discomfort. 3. medication: patients can also follow the doctor’s instructions to use anti-fatigue eye drops, such as seven leaves of digitalis bisabolol eye drops and other medication to relieve eye discomfort. It is recommended that patients with significant eye swelling and pain after staying up all night should consult a doctor in time to assess their condition and take treatment under the guidance of the doctor.