Prolonged menstruation with elevated platelets may be due to uterine fibroids, sex hormone level disorders and other causes, or it may be a physiological manifestation. When uterine fibroids and sex hormone level disorders occur in women, the amount of menstruation may increase, the duration of menstruation is prolonged, and some patients may also experience menstrual disorders. When menstruation time is prolonged, the body reacts to produce more platelets, which will be manifested as elevated platelets, mostly mildly elevated, and can be gradually returned to normal after the end of menstruation. If platelet elevation is obvious, one should consult the hematology department in time to complete bone marrow aspiration and MPN gene test to exclude the possibility of chronic myeloproliferative neoplasms. Some women have long menstrual period since menarche, which is mostly physiological. However, it is still recommended to consult the gynecology department in a timely manner to improve the gynecological ultrasound and sex hormone six tests to exclude the possibility of gynecological pathology.