There are differences between triple therapy and quadruple therapy for gastric problems, both in terms of the drugs used and the therapeutic effect. 1. The drugs used are different: triple therapy refers to the combination of two antibiotics and a proton pump inhibitor. Commonly used antibiotics include clarithromycin, metronidazole, amoxicillin, etc. Commonly used proton pump inhibitors include omeprazole and pantoprazole. Quadruple therapy is based on triple therapy, plus a bismuth, bismuth has a protective effect on the gastric mucosa, commonly used bismuth including colloidal bismuth pectin, bismuth potassium citrate and so on. 2. Different therapeutic effects: quadruple therapy has one more bismuth agent than triple therapy. When bismuth agent is used in combination with proton pump inhibitors and antibiotics, it can improve the eradication rate of Helicobacter pylori, and also has a protective effect on gastric mucous membrane, which can effectively alleviate the symptoms of ulcer. When patients feel uncomfortable in the stomach, they should go to the hospital for examination in a timely manner, and self-medication is not recommended to avoid delaying the condition.