Non-liquefaction of liver abscess may mean early stage of the disease, severe bacterial infection, improper choice of antibiotics and other reasons. 1. Liver abscess is a purulent lesion of the liver caused by bacterial and other microbial infections. Early stage of the disease manifests as fever, nausea and vomiting, abdominal pain and diarrhea, enlarged liver, etc. Liver CT examination reveals a rounded, well-defined, unevenly densified low-density area, with no change in the enhancement scan. If liver abscess is in the early stage, it is recommended to observe it for a period of time, and it may liquefy as the disease progresses. 2. If the liver abscess does not liquefy to form pus, it may be due to the change of bacterial type of infectious disease or the aggravation of the original infection, it is recommended to clarify the pathogenic bacteria, use more sensitive antibiotics, and at the same time, can take the puncture method of pus pumping treatment. 3. The slight effect of the original antibiotics may lead to liver abscess not liquefied, it is recommended to choose the pathogenic bacteria sensitive antibiotics, full amount, full course of antibiotics can accelerate the liquefaction of liver abscess, discharge pus as soon as possible. During the treatment of liver abscess, it is necessary to pay attention to rest, eat a light diet, appropriate exercise to increase the body’s resistance, follow the doctor’s instructions to take medication, and if necessary, choose the surgical puncture pus extraction treatment.