Diffuse injury of both kidneys means that there is some kind of disease in the kidneys suggested in CT or ultrasound examination. Diffuse injury of both kidneys is mainly caused by acute glomerulonephritis, chronic glomerulonephritis, pyelonephritis, nephrotic syndrome, diabetic nephropathy and other diseases. The clinical manifestations of patients are proteinuria, hematuria, edema, hypertension, oliguria, polyuria, anuria and other symptoms. Dual kidney diffuse injury auxiliary tests are laboratory tests, including routine blood, urine routine, 24-hour urine protein quantification, renal function tests, etc.; imaging tests including ultrasound, CT examination; pathological biopsy to do renal puncture biopsy to determine the type of its pathology. Patients with diffuse injury of both kidneys have different treatment programs according to the type of disease, including symptomatic treatment, drug treatment, surgical treatment, dialysis treatment and so on. Symptomatic treatment requires diuresis to reduce swelling and blood pressure; drug treatment mainly includes antihypertensive treatment such as nifedipine, glucocorticoid treatment such as prednisone, immunosuppressant treatment such as cyclophosphamide, etc.; renal replacement therapy should be considered for end-stage irreversibility; such as dialysis treatment and renal transplantation surgery, and there are peritoneal dialysis and hemodialysis treatment for dialysis methods. If you find diffuse damage of both kidneys, you should go to the hospital in time, follow the doctor’s instructions to improve the examination, clarify the cause of the disease, and treat the symptoms, so as not to miss the best time for treatment.