What happens when entecavir is discontinued for a month depends on the patient’s original condition, which may worsen, and in severe cases, liver failure may occur. If the patient’s virus was already negative before the withdrawal, the sudden withdrawal may cause the virus to replicate again in large quantities in the body, leading to severe hepatitis symptoms. If the patient’s virus had dropped by only a small amount before discontinuation, the rebound of the virus caused by discontinuation may be relatively small, and the patient’s hepatitis caused by discontinuation will be mild. However, if the patient already has severe cirrhosis or severe hepatitis, sudden withdrawal may result in irreversible liver failure due to the poor condition of the liver. Common adverse reactions to the drug are dizziness, nausea and vomiting. It is contraindicated in patients who are allergic to entecavir. Patients are advised not to discontinue the drug as much as possible, and if they need to change the drug, they are advised to seek medical advice in time to communicate with the doctor and then follow the doctor’s instructions for gradual conversion.