Femoral fibrous dysplasia can be treated with regular review, medication, scraping and bone grafting, and deformity can be treated with lesion removal and osteotomy and orthopedic treatment. 1. Regular review: for asymptomatic patients found during physical examination, review can be done every 6 months to observe the development. 2. Drug treatment: Bisphosphonates are important drugs for the treatment of the disease, which can significantly reduce bone pain, such as oral alendronate, injection of pamidronate and so on. However, attention should be paid to the adverse reactions of this kind of drugs. 3. Scraping and bone grafting: when the symptoms of femoral fibrous malarchitecture are gradually significant, the focal scraping and bone grafting treatment can be carried out to avoid deformity in the later stage. 4. Focal removal + osteotomy and orthopedic treatment: if the proximal femur deformity is obvious, we can carry out focal removal and implantation, combined with osteotomy and orthopedic treatment if necessary, in order to restore the force line and stability, as well as internal fixation and other treatments. Fibrous dysplasia of femur, also known as abnormal proliferation of bone fiber, is a kind of genetic mutation of non-genetic bone development disorders, manifested as pain, swelling, deformity or pathological fracture will occur in the later stage, therefore, fibrous dysplasia of femur should be diagnosed as early as possible, and according to the specific circumstances of the corresponding treatment.