Insulin resistance refers to a decrease in the efficiency of insulin to promote glucose metabolism, and the body compensates by secreting more insulin to maintain blood glucose stability. Diabetes, insulin resistance or abnormal glucose tolerance combined with any two of the following indicators can diagnose insulin resistance syndrome: 1, blood pressure ≥ 160/90mmHg 2, triglycerides ≥ 1.7mmol/L, low HDL 3, centripetal obesity 4, body mass index BMI>30kg/m2; 5, waist-to-hip ratio, men>0.9, women>0.85; 6, hyperuricemia. 7, microalbuminuria. Common causes are genetics (genetic mutation, abnormal insulin structure or presence of antibodies), obesity (the main cause, especially central obesity), hyperglycemia, hyperlipidemia, pregnancy, endocrine disorders (reduced activity of leptin and lipocalin, increased insulin antagonist hormone), glucocorticoids, enhanced activity of tumor necrosis factor TNF-a (promoting lipolysis, causing an increase in plasma free fatty acids, leading to insulin resistance and hyperinsulinemia, etc.). There is no effective treatment for primary or hereditary insulin resistance. People with family history of diabetes, hypertension, hyperlipidemia and low birth weight should avoid obesity and prevent insulin resistance as much as possible. For people with existing insulin resistance, individualized treatment should be carried out to reduce weight and control the progression of the disease. General recommendations are as follows: 1, less sedentary, more exercise: modern transportation is convenient and fast, work is mostly mental labor, activity time and intensity greatly reduced, resulting in a decline in body metabolic rate, energy consumption reduced, obesity increased. Commuters should make full use of their respective conditions to strengthen activities, such as early down a few stations of the subway or bus walking to and from work, can climb the stairs without elevators, do not want to go out after dinner activities can be done in the living room or brisk walking, etc.. Exercise is more about strengthening the body, not just consuming calories. 2, drink more water: many people do not have the habit of actively drinking water, are thirsty when you want to drink water, drink water is mostly half a glass of water directly into the stomach, which only relieves the thirst, to help metabolize waste in the body is slightly less effective. Should develop the habit of active, a small amount, many times to drink water, mainly plain water and light tea. Drink no less than 1500 ml of water per day. 3, fat and nut intake needs to be controlled: the main source of body fat is frying oil, nuts, etc., excessive intake of these foods will lead to overweight, obesity. It is recommended that 25-30 grams of oil for frying every day, like to eat nuts can be eaten every other day, each time the amount of 2 walnuts is enough. In addition, fried fried food do not often eat, eat when you need to reduce the intake of other foods. 4, snacks, desserts, fruit and other sweet food intake too much: excessive sweet food can also lead to triglyceride overload, so do not add extra white sugar, brown sugar, etc., fried dishes, soy milk, coffee, etc. Try to drink without sugar, fruit not more than half a pound a day, cakes, snacks do not often eat. 5, insulin sensitizers or glucose-lowering drugs should be taken according to medical advice, not just adjust the dose, drug adjustments need to consult with the doctor. Other drugs that may lead to insulin resistance should also be taken in consultation with the relevant doctor. 6. Actively correct lipid metabolism disorder: high triglyceride or high free fatty acid will aggravate insulin resistance, and active diet and medication are needed to lower lipid. The above recommendations are applicable to insulin resistance in general. In case of special circumstances, individualized dietary intervention or medication adjustment should be carried out in consultation with a doctor.