When it comes to spinal-derived pain, it is actually not a disease, but a general term for a category of diseases or syndromes due to various spinal causes. Common causes include lesions of the cervical discs, cervical small joints, lumbar discs, and small joints of the lumbar spine, as well as systemic diseases that manifest as spinal-derived pain, such as spondylolisthesis and ankylosing spondylitis. In the elderly, degenerative changes of the spine are common, including osteoporosis, degenerative discs, small vertebral joints, and spinal stenosis. Minimally invasive interventions for pain of spinal origin are not a single treatment, but a group of minimally invasive treatments under the guidance of imaging. Therefore, do not be confused by “a needle for cervical spondylosis” or “one injection can cure disc herniation”. The specific minimally invasive access method should be decided according to the patient’s clinical symptoms and imaging changes. With the advancement of modern minimally invasive techniques and the understanding of spinal origin pain, many patients for whom conservative treatment in the past was ineffective or required open surgical treatment can be treated by minimally invasive interventional methods. The latest modern research and clinical observations suggest that 70% of spinal-derived pain is related to inflammatory reactions caused by various factors, and less than 30% of patients are related to mechanical factors of the spine. The Pain Medicine Center of Nanjing General Hospital of Nanjing Military Region uses the latest minimally invasive interventional technology to reduce the intradiscal pressure of the intervertebral disc by means of nucleus pulposus clamping and low-temperature thermal coagulation to reduce the inflammatory reaction within the disc, and at the same time to mechanically release the intervertebral foramen through which the spinal nerve passes, flush the inflammatory material, and eliminate the edema of the nerve root, so that many patients with cervical spondylosis and lower back pain can be effectively treated. Some patients who do not have significant symptom relief after open surgery can also achieve better results with the new technique. All operations are performed within a 1-5 mm needle, resulting in minimal trauma, rapid recovery, and a 3-5 day hospital stay. These patients need to be strictly screened or diagnosed by discography, and only by strictly mastering the indications for surgery can good results be achieved. The development trend of modern medicine is to obtain maximum symptomatic improvement with minimal trauma, and this is also the driving force behind the vigorous development of minimally invasive interventional therapy.