Hepatic iron overload is often treated clinically with bloodletting therapy, iron excretion therapy, dietary iron restriction, etc. The details are elaborated as follows: Hepatic iron overload is caused by iron supply and absorption in the body exceeding the needs of the organism, causing excessive total iron in the body and leading to iron deposition in the liver. The disease can be caused by congenital developmental abnormalities or by excessive iron intake over a long period of time. With iron overload in the liver, patients need to go to a regular hospital for examination, and after the diagnosis is established, the treatment requires avoiding the intake of foods containing too much iron, such as animal blood and animal liver. Meanwhile, the condition can be relieved by bloodletting treatment or iron chelating treatment using iron chelators such as deferoxamine and deferiprone. Hepatic iron overload will lead to liver cell damage or death, and then cause liver fibrosis or even cirrhosis, and in severe cases, it may lead to liver failure of the patient. Therefore, we need to pay enough attention to this disease, actively cooperate with the doctor’s treatment, and follow the doctor’s instructions for the use of medication.