The first thing that patients must be clear about is that mites are common to the human body, not only on the human skin, but also in the environment where the human body lives for a long time and widely. It is very unrealistic to apply drugs to get rid of all the mites outside the body. Moreover, if the skin of the patient, such as acne, is not very serious, it is not necessary to apply these so-called mite killing drugs for treatment. Generally patients with mite related skin diseases, the most common is actually rosacea, but rosacea to be removed, it is generally recommended to apply topical medications such as metronidazole or oral medications, the application of toothpaste is not able to play an equivalent alternative role. Applying toothpaste to the skin will only cause further irritation to the already fragile skin. In clinical practice, many patients who blindly apply toothpaste experience localized skin redness, swelling, peeling and pain.