Neocoronavirus vaccine is short for new coronavirus vaccine, which generally has no effect on thyroid nodules. Neocoronavirus vaccination can effectively prevent neocoronavirus infections. There is no obvious correlation between neocoronavirus vaccination and thyroid nodules, and the contraindications for neocoronavirus vaccination do not include thyroid nodules. Thyroid nodules are masses in the thyroid tissue that occur after abnormal proliferation of thyroid cells, and patients are generally not affected by the New Crown vaccine. Patients with thyroid nodules who require surgical treatment are not recommended to receive the New Crown vaccine at this time to avoid adverse reactions. Patients who are allergic to any of the components of the New Crown vaccine are prohibited from receiving the New Crown vaccine. Common adverse reactions after vaccination include headache, fatigue, fever, etc., but they usually subside on their own. If patients with thyroid nodules need to receive New Crown Vaccine, they should consult their doctors in advance before vaccination.