There is no such thing as better tadalafil or sildenafil, patients should follow the doctor’s instructions to use medication. 1. Tadalafil: Tadalafil is commonly used in clinical practice to treat erectile dysfunction in men. Usually patients reach the average maximum observed plasma concentration 30 minutes to 6 hours (median time 2 hours) after a single oral administration, and the drug effect is generally not affected by diet. Adverse reactions such as headache, dyspepsia, and nasal congestion may occur in some patients after administration of the drug. During the application of tadalafil, the concomitant application of any form of nitrates, guanylate cyclase stimulators is contraindicated, and is contraindicated in cases of definite drug allergy. 2. Sildenafil: Sildenafil is also used in the treatment of erectile dysfunction in men, usually sildenafil is rapidly absorbed, and the peak plasma concentration is reached after 30 to 120 minutes (median 60 minutes) of oral intake in fasting state. The rate of absorption is reduced if the drug is taken with a high-fat diet. Adverse reactions such as headache, flushing, dyspepsia, visual abnormalities, and nasal congestion may occur in some patients after administration of the drug. The application of sildenafil is contraindicated if there is a clear allergy to the components of the drug. At the same time, it is contraindicated to use with guanylate cyclase agonists and nitrate drugs to avoid accidents. It is recommended that patients follow the doctor’s instructions according to their own actual situation, and not to use drugs indiscriminately, so as to avoid the occurrence of accidents.