HPV skin and mucosal types represent different tissue sites that the virus primarily invades and cannot be directly compared to which type is more severe. HPV viruses are categorized into high-risk and low-risk types based on the risk of causing disease, and into cutaneous and mucosal types based on the tissues they invade. Skin low-risk types include: HPV-1, 2, 3, 4, 7, 10, 12, 15, etc., which are associated with common warts, flat warts, plantar warts, etc. Skin high-risk types include: HPV-5, 8, 14, 17, 20, 36, 38, which are associated with verrucous epidermal dysplasia, and may lead to malignant tumors associated with HPV infections, such as vulvar cancer, penile cancer, anal cancer, prostate cancer, bladder cancer. Mucosal low-risk types include: HPV-6, 11, 13, 32, 34, 40, 42, 43, 44, 53, 54, etc., often infected genital, anal, oropharyngeal, esophageal mucosa and other parts of the body, appearing warts; Mucosal high-risk types include: HPV-16, 18, 30, 31, 33, 35, 39, 52 and the onset of cervical cancer, rectal cancer, oral cancer, tonsil cancer, etc. Related to the development of cervical cancer, rectal cancer, oral cancer, tonsil cancer and so on. It can be seen that both skin high-risk types and mucous membrane high-risk types may lead to tumor development, HPV vaccine can effectively prevent HPV infection, in addition to the need to do less to go to public bathrooms, avoid sharing personal belongings with others.