Pain aggravation after taking closed injection should be treated according to the reasons, such as general treatment, drug treatment, physical therapy and surgical treatment, etc. Reasons for pain aggravation include damage to peripheral nerves, improper operation, and after anesthesia. 1. Damage to peripheral nerves: when playing closed in the wrong position, the injection needle stimulates the peripheral nerves, resulting in pain aggravation. Should immediately stop the injection, if the pain is serious, you can take oral non-steroidal anti-inflammatory drugs, such as celecoxib, etc., to relieve the pain symptoms. 2. Improper operation: improper operation of the closed needle, not strictly follow the aseptic operation, leading to infection, secondary pain aggravation. According to the drug sensitivity test to choose the appropriate use of antibacterial drugs, such as penicillin, imipenem, etc.. If the local formation of abscess, also feasible surgical incision drainage. 3. After anesthesia: when playing closed needle will use anesthetics, after playing, anesthesia drug effect disappears, there will be pain aggravation. At this time, you can carry out local ice and brake to reduce pain, if the pain is serious, you can choose to use non-steroidal anti-inflammatory drugs, such as ibuprofen. Pain aggravation after the closed injection may also exist for other reasons, if it continues to be unrelieved, it is recommended to go to a regular hospital, by the specialist to determine the specific causes, and then targeted treatment or treatment, the above drugs need to be used under the guidance of a doctor.