Thyroid puncture biopsy is associated with certain dangerous risks. The dangers of thyroid puncture may be bleeding, pain, infection, nerve damage, etc. However, thyroid puncture biopsy is a very minimally invasive procedure, which is not very harmful and the probability of danger is not high, so patients do not need to worry too much. 1. Bleeding: The thyroid gland is surrounded by two blood vessels, the common carotid artery and the internal jugular vein. If the procedure is not performed properly, there is a chance that the puncture needle may accidentally enter into these two blood vessels, but the probability is generally not high. The bleeding can be stopped by applying pressure for a period of time after the puncture. 2. Pain: Even if the patient is anesthetized, pain can still be felt during the puncture, but it is generally tolerable. 3. Infection: It is mainly caused by the operator’s failure to comply with the rules of asepsis, and the probability of infection is also very small. 4. Nerve damage: There is a recurrent laryngeal nerve in the thyroid area, which can affect a person’s voice. If this nerve is damaged, the patient will be hoarse or even have difficulty in making a sound. However, since this surgery is less invasive, the nerve can slowly return to its normal state after it is damaged. To minimize the incidence of these dangers, it is recommended that the biopsy be performed under ultrasound guidance. If any after-effects of thyroid puncture biopsy occur, please seek medical attention promptly.