Positive neocoronavirus antigen does not confirm infection with neocoronavirus and further nucleic acid testing is required. Neocoronavirus tests are available as antigen, antibody and nucleic acid tests. Neocoronavirus antigen test is a small, convenient and rapid kit that is usually used in primary healthcare organizations or at home, and the test is easy and quick to perform. Compared with nucleic acid testing, antigen testing is less accurate, and nucleic acid testing is more complex, sensitive, and takes longer to detect. If a patient is neocoronavirus antigen-positive, it can be used for rapid management and early triage, but it cannot confirm the diagnosis of a patient with neocoronavirus. Confirmation of a diagnosis of neocoronavirus infection requires further nucleic acid testing, which can accurately determine whether or not a patient is infected with neocoronavirus. In conclusion, the new crown antigen positive need to be in accordance with the new crown pneumonia diagnosis of patients or new crown virus infection to take appropriate measures, further nucleic acid testing. Tip: In this article, “new coronavirus pneumonia” and “new coronavirus pneumonia” have been renamed to “new coronavirus infection” on December 26, 2022, as announced by the National Health Commission.