During the operation of cardiopulmonary resuscitation for patients with cardiac and respiratory arrest, a clear judgment of the patient’s cardiac and respiratory arrest should be made first, and the operation of cardiopulmonary resuscitation should be started as soon as the patient reaches the resuscitation-related index. In the process of chest compressions, the main points to be noted are that the compression site and operating position should be accurate, and that the consensus requirements for compression frequency, compression depth, compression and relaxation time, and compression to ventilation ratio should be clearly and strictly grasped and followed. Under the premise of ensuring the correct operation of chest compressions, the continuity of compressions should be maximized and the number and duration of interruptions of compressions should be reduced, which is an important guarantee of high-quality chest compressions. During the process of artificial respiration after opening the airway, the associated adverse injury and damage to the patient caused by hyperventilation should be avoided. For patients with ventricular fibrillation or pulseless ventricular tachycardia who are suitable for electric defibrillation, defibrillation should be performed as soon as possible, or even defibrillation can be performed before CPR if conditions permit.