Long-term application of adrenocorticotropic hormone discontinuation may have withdrawal reaction, need to be gradually reduced under the guidance of a doctor. Long-term application of adrenocorticotropic hormone, negative feedback inhibition of pituitary secretion of pro-adrenocorticotropic hormone, its own adrenocortical secretion is suppressed, if the drug is suddenly discontinued, there will be withdrawal reactions, including including withdrawal symptoms and rebound phenomenon. Withdrawal symptoms include weakness, nausea, vomiting, hypotension, hypoglycemia, shock and other signs of adrenocortical insufficiency, and in severe cases, adrenal crisis. The rebound phenomenon is that after long-term use of adrenocorticotropic hormone treatment, the symptoms can be relieved, but will become dependent on adrenocorticotropic hormone, and the original disease will recur or deteriorate after suddenly stopping the drug or reducing the dosage. Patients who have been using adrenocorticotropic hormone for a long period of time should gradually reduce the drug under the guidance of the doctor, and should not stop the drug on their own in order to avoid serious adverse effects.