Most of the low-grade squamous intraepithelial lesions are not very serious, but they need to be observed and followed up as prescribed by the doctor. Cervical squamous intraepithelial lesion is a common cervical lesion, which mostly occurs in women aged 25-35 years old, mainly due to human papillomavirus infection, sexually transmitted diseases and other causes. It can be categorized into low-grade squamous intraepithelial lesion (LSIL) and high-grade squamous intraepithelial lesion (HSIL), but most of the LSIL can subside naturally, and needs to be observed and followed up according to the doctor’s prescription. During the follow-up of LSIL, colposcopy, cervical cytology and human papillomavirus testing should be reviewed regularly. When LSIL has persisted for 2 years, it needs to be treated according to the doctor’s advice, and ablative treatments such as freezing and laser can be chosen; however, when it develops into HSIL, ablation or cervical conization is needed, and it is necessary to review the patient’s health after the treatment on a regular basis. When patients develop low-grade squamous epitheliopathy, it is recommended that they seek treatment promptly to avoid delay.