Drinking alcohol after piperacillin infusion should be closely monitored for any discomfort and skin irritation. Piperacillin is a semi-synthetic penicillin antibiotic, unlike cephalosporin antibiotics, drinking alcohol after piperacillin infusion does not usually cause “disulfiram reaction”. However, it is not recommended to drink alcohol while taking piperacillin. Alcohol damages the mucous membrane of the gastrointestinal tract and affects the metabolism of the liver, which is detrimental to the absorption and utilization of the drug, as well as to the health of the body. At the same time, after the infusion of penicillin drugs are prone to diarrhea, rash, dizziness, headache, nausea, vomiting, fever and other adverse reactions, should be considered piperacillin itself due to the drug, and drinking alcohol can aggravate the above symptoms. If you drink alcohol after the infusion, it is recommended to closely observe the body for any discomfort and skin allergies, and at the same time, you can drink more water and have a regular work and rest schedule. If you feel unwell after drinking alcohol after piperacillin infusion, you should consult the hospital in time to avoid delaying your condition.