Eyeball rotation with tugging pain may be caused by eye fatigue, may also be suffering from optic neuritis, scleritis and other diseases caused. 1. Eyestrain: Eyestrain is mostly caused by long time watching TV, cell phone and other electronic product screens at close range, patients will experience soreness, dryness and other symptoms, patients will also experience blurred vision, eye swelling and pain and other symptoms. 2. Optic neuritis: optic neuritis is usually caused by eye infections, poisoning, autoimmune diseases, etc. The main symptoms of the patients are sharp decrease in visual acuity, traction pain or retro-orbital pain during eye movement, mostly monocular, and some of the patients can also involve both eyes. 3. Scleritis: Scleritis is usually caused by fungal infection, trauma, inflammation and other reasons, the patient’s eyes will have obvious pain and discomfort at night pain will be aggravated, and accompanied by varying degrees of visual acuity loss, intraocular pressure rise and other symptoms. In more serious cases, eyelid edema and deep scleral vasodilatation may also occur. It is recommended that patients who experience tugging pain with eye rotation seek prompt medical attention to evaluate their condition and follow doctor’s instructions for treatment.