Most people think that smoking primarily causes lung cancer, but the dangers of smoking are much more than that. Smoking, including secondhand smoke, is not only responsible for lung cancer, but is also strongly associated with the risk of many other tumors. Lung cancer Smoking is internationally recognized as one of the most important factors in causing lung cancer. According to statistics, the incidence of lung cancer increases 13 times if you smoke 10 cigarettes a day; 20 times if you smoke 20 cigarettes a day; and 65 times if you smoke 40 cigarettes a day. The mortality rate of lung cancer among non-smoking women due to passive smoking by their husbands is 1-2 times higher than that of women whose husbands do not smoke. 9 out of 10 patients who die of lung cancer are smokers. In China, 70% to 80% of lung cancer in men is caused by smoking, and about 30% of lung cancer in women is attributed to smoking and passive smoking. The earlier the age of smoking, the greater the risk of lung cancer. The lung cancer mortality rate for those who have smoked for 60 years is about 100 times higher than for those who have smoked for 20 years. Cigarette smoke contains more than 3,000 toxic chemicals, the most important of which are nicotine, carbon monoxide, cyanide, many carcinogens present in tobacco tar, radioactive isotopes, and heavy metals. Carcinogenic substances produced by tobacco combustion include benzo(a)pyrene, nitrosamines, beta-naphthylamine, cadmium, and radioactive polonium. There are also carcinogenic substances such as phenolic compounds. People aged 55-74 with a history of smoking ≥30 packs/year should receive annual small-dose CT lung cancer screening, even if they have quit smoking within 15 years. Bladder Cancer There are many causes of bladder cancer, one of the important and often overlooked causes is smoking. In developed countries, bladder cancer caused by smoking accounts for 50% to 60% of all bladder cancers. The risk of bladder cancer for smokers is four times higher than that for nonsmokers, and as the number of cigarettes smoked increases and the age of smoking increases, the risk of bladder cancer increases accordingly. Women are more sensitive to the dangers of smoking, and women who smoke are more likely to develop bladder cancer than men who smoke. In addition, children who smoke passively in a long-term smoking environment have a significantly increased risk of bladder cancer when they grow up. Tobacco contains a large number of toxic substances, of which the main ones closely related to bladder cancer are aromatic amines and acrolein, and the pyrolysis products of these compounds are strong carcinogens of bladder cancer. The most common symptom of bladder cancer is hematuria in the form of “flesh-washing water”, usually without pain and other accompanying symptoms. If middle-aged and elderly people have unexplained hematuria, they should not take it lightly, and if they are “smokers”, they should pay more attention to it and go to the hospital in time to identify the cause of hematuria. Pancreatic Cancer Pancreatic cancer is known as the “king of cancers” and is extremely malignant! Among the many causes of pancreatic cancer, smoking is the only risk factor recognized to have a clear relationship with the development of pancreatic cancer. The tobacco-specific nitrosamines (NNK) produced by the nitrosation reaction of nicotine during combustion are very powerful carcinogens, and the binding of NNK to its receptors can stimulate the proliferation of pancreatic ductal adenocarcinoma cells. For the prevention of pancreatic cancer, the first thing is to have regular medical checkups, regular rest and diet, stay away from smoking and alcohol, be more active and exercise regularly. If symptoms such as abdominal pain, jaundice and wasting occur, it is important to seek medical consultation and early treatment. Nasopharyngeal cancer The incidence of nasopharyngeal cancer is high in China and some countries in Southeast Asia. Many studies point out:Smoking, salted fish, EBV and genetic factors are important risk factors in high incidence areas. Among subjects in Guangdong, those who smoked 20 to 40 packs per year and those who smoked more than 40 packs per year had a significantly higher risk of developing nasopharyngeal cancer compared to non-smoking subjects. In China, smoking is not only a risk factor for the development of nasopharyngeal carcinoma in individuals, but is also associated with the development of EBV in healthy men who are seropositive for EBV, and smoking induces EBV activity. Gastric cancer Several prospective studies have found a dose-response relationship between smoking and the risk of gastric cancer development. The risk of gastric cancer increased with increasing daily cigarette consumption and duration, and was associated with increased recurrence and mortality from gastric cancer. Prostate cancer Smoking may increase the odds of death in patients with prostate cancer. Smokers have a 61% higher chance of dying from prostate cancer compared to never smokers, and a 61% higher chance of recurrence after prostate cancer has been cured. Prostate cancer patients who have quit smoking for 10 years or more are almost as likely to die as those who have never smoked.