Waking up from hunger in the middle of the night is mainly due to two reasons, firstly, waking up from hunger in the middle of the night may be due to insufficient food intake, resulting in a sense of hunger, which mostly occurs in people who blindly lose weight or have an irregular diet, such patients will disappear from hunger as long as they eat in time, which is a normal physiological situation. Secondly, waking up in the middle of the night may also be caused by certain diseases, such as duodenal bulb ulcers, such patients may also be accompanied by abdominal pain and other symptoms in addition to hunger, for such patients should go to the hospital in a timely manner for electronic gastroscopy to diagnose the cause and then carry out targeted treatment. For patients who wake up hungry in the middle of the night due to pathological factors, they must pay more attention to their diet, which should be light and easy to digest, and try to eat regularly.