Hypoechoicity seen at the bottom of gallbladder is the result of ultrasonography, which does not exclude gallbladder polyps and adenomyosis of gallbladder, which are not serious and can be cured by timely treatment; some patients are due to gallbladder cancer, which is more serious, and the specific degree should be judged according to the staging and typing. 1. Gallbladder polyps: when repeatedly stimulated by inflammation or cholesterol abnormality, gallbladder polyps can appear, which can be manifested as hypoechoic. 2. Adenomyosis of gallbladder: it is considered as a benign disease, which is mainly due to the proliferation of the mucosa of gallbladder, which is caught into the muscular layer, causing the muscular layer to have thickening at the same time. 3. Gallbladder cancer: it belongs to malignant tumor, when the tumor gradually increases in size and causes bile stasis, it will also cause hypoechoic. Gallbladder cancer is more serious, if not treated in time, the cancer cells will metastasize and spread, which will affect the surrounding tissues and organs. If it is advanced gallbladder cancer, it will also threaten the patient’s life. If hypoechoicity is found at the bottom of gallbladder through imaging examination, it should be reviewed in time, and the cause of the disease should be analyzed through pathological biopsy, and if there is a tendency of cancer, radical treatment should be carried out in time so as to avoid delaying the disease.