Limb ulcers are broken or ulcerated limbs that occur on the body. The vast majority of patients think that they have to see a dermatologist or surgeon when they have an extremity ulcer, but they do not know that many extremity ulcers, especially those that are difficult to heal and close, are caused by peripheral vascular disease. The peripheral vascular diseases that cause limb ulcers can be divided into two main categories. Ulcers caused by arterial disease tend to occur at the end of the limb and are painful and severe, characterized by irregular edges at first and later jagged, with grayish-white granulation tissue covering the bottom. It does not bleed easily when touched. These diseases are often preceded by ischemic manifestations of the limb before they break in the early stages: such as coldness, coldness, soreness, numbness, and pain in the limb, which is especially pronounced at night. The main arterial diseases causing limb ulcers are: atherosclerotic occlusive disease, thrombo-occlusive vasculitis, diabetic vasculopathy, Raynaud’s syndrome, etc. Since most of the ulcers caused by arterial diseases are ischemic ulcers, their treatment should focus on improving the ischemic state of the limb and actively controlling the risk factors. Treatment includes: use of vasodilators such as Pepcid, Ambulac, Kaiser, etc.; control of hypertension, hyperlipidemia and diabetes; anticoagulation and antithrombotic medication to reduce blood viscosity; smoking is also an important risk factor, and active cessation of smoking is required; bypass surgery and interventional treatment are also effective methods to improve the ischemic state of the limb. The ulcers caused by venous disease are characterized by a shallow and irregular ulcer with a large area and easy bleeding when touched. They do not usually cause pain. The main venous diseases causing limb ulcers are varicose veins of lower limbs, deep vein reflux disorders, and sequelae of acute deep vein thrombosis. The cause is usually lower limb venous hypertension leading to stasis ulcers, so its treatment should be based on improving the circulatory status of the limb and promoting blood return. 1 is symptomatic, including local wound dressing change, prevention of infection, etc. 2 is the cause, according to the cause of venous hypertension treatment. If the cause of venous hypertension is saphenous varicose vein combined with valve involvement of the traffic branch, the varicose saphenous vein trunk can be removed, the femoral saphenous valve can be closed, and the traffic branch can be surgically ligated; if the cause of venous hypertension is deep vein thrombosis, it should be treated according to deep vein thrombosis; if there is deep vein valve insufficiency, surgery or medication can be considered according to the location of the valve lesion to reduce the regurgitation of the valve. In conclusion, limb ulcers caused by peripheral vascular diseases often bring great inconvenience to people’s work and life because they are chronic, difficult to heal, and prone to recurrence. In particular, ulcers caused by arterial diseases can eventually lead to serious consequences of amputation or finger (toe) amputation if they are not controlled in a timely and effective manner. Therefore, patients with limb ulcers should not forget to see a vascular surgeon.