After eliminating the drug contraindications of febuxostat and sodium bicarbonate, these two drugs can be taken together. Febuxostat can play a role in lowering the blood uric acid concentration in the patient’s body, and sodium bicarbonate can play a role in promoting renal excretion, alkalizing the effect of uric acid, the two do not have drug interactions or contraindications, so they can be taken together for the treatment of gout or hyperuricemia. Patients receiving mercaptopurine therapy or azathioprine therapy and patients with allergy to the drug components are prohibited to take Febuxostat, while patients with restricted sodium intake, patients with allergy to the drug components of sodium bicarbonate, and patients on urotropin therapy should not take sodium bicarbonate, and drug contraindications should be ruled out prior to the administration of both drugs. Adverse reactions such as nausea, hepatic impairment and arthralgia may occur with the use of Febuxostat. Note that liver function tests are performed before the first dose and liver and kidney function and blood tests are monitored during administration. Not recommended for asymptomatic hyperuricemia. Use of sodium bicarbonate may produce carbon dioxide gas when neutralizing stomach acid, resulting in belching (burping). Note that this product should not be used for more than seven days and should not be used by those with gastrointestinal bleeding of unknown origin. Both drugs are recommended to be used under the supervision of a physician, and patients who need to take febuxostat and sodium bicarbonate are advised to go to the relevant departments of regular hospitals and not to take the drugs by themselves.