Frequent muscle spasms after taking hormones may be related to electrolyte disorders caused by hormones, such as low calcium. Muscle spasms are commonly associated with low calcium convulsions, and oral hormonal drugs can lead to osteoporosis, gastric ulcers, electrolyte disorders, elevated blood glucose, necrosis of the femoral head, elevated white blood cells, and elevated blood lipids. It can also lead to electrolyte disorders, most commonly hypokalemia and hypocalcemia, and of these, hypocalcemia may lead to muscle spasms. It is recommended that patients taking oral hormones be routinely treated with calcium supplementation, potassium supplementation, and protection of gastric mucosa. There may be other reasons for frequent muscle spasms after taking hormones. If the patient’s muscle spasms frequent attacks, it is recommended to consult a doctor in a timely manner, under the guidance of a professional physician for examination, to clarify the cause of the diagnosis and treatment.