The longer course of treatment for infertility (generally 3 months) is based on the fact that it takes approximately 90 days for sperm to be produced and mature enough to gain the ability to fertilize. The process of human spermatogenesis can be divided into six phases, each with a specific time and cell combination, and the six phases constitute a cycle. Human spermatogenesis takes about four and a half cycles, and since a cycle lasts 16 days, the process of human spermatogenesis takes about 70 days. Spermatogenesis also requires 19 to 23 days for full maturation in the epididymis. Therefore, from the time sperm are produced to the time they are matured and expelled from the body, it takes about 90 days. Therefore, patients receiving medication should not be anxious or think that the medication is ineffective, but should insist on taking the medication for 3 months before the effect will appear, especially in cases of oligospermia or azoospermia where the cause is in the testes.