The most serious complication of tibiofibular fracture is crush syndrome. If a tibiofibular fracture occurs, it is a closed fracture and the limb is pressed into the earth or foreign objects. After release of compression, due to bleeding, exudation, edema and swelling at the fracture break end, it can cause tension blisters and hemorrhages, and if the pressure is any greater it can cause fascial septal area syndrome, also called osteofascial compartment syndrome. When the pressure is high, it will lead to venous reflux obstruction and arterial blood supply obstruction, the muscles in the limb will be ischemic and necrotic, and the potassium ions inside the necrotic muscle cells will overflow, leading to myoglobin, urinary hyperkalemia, acute renal failure, etc., which will lead to the loss of the patient’s life, so crush syndrome is the most serious complication of tibiofibular fracture.