Total bilirubin 60umol/L indirect bilirubin 50umol/L is significantly higher than normal, may be hemolytic anemia and various liver diseases, hemolytic anemia should be applied glucocorticoids, immunosuppressants, etc.; liver disease should be hepatoprotective and for the cause of liver damage treatment. Indirect bilirubin comes from the destruction of red blood cells and has not been glucuronidated by the liver. When the destruction of red blood cells exceeds the liver’s capacity, indirect bilirubin will be high, and then total bilirubin will also be high. 1. Blood system diseases: autoimmune hemolytic anemia caused by various connective tissue diseases, lymphoma, leukemia, etc., hemolysis caused by blood group incompatibility, etc., the destruction of red blood cells exceeds the processing capacity of the liver, and the indirect bilirubin and total bilirubin can be high, and glucocorticosteroids and immunosuppressants should be applied to treat the disease. 2. Liver diseases: cirrhosis, viral hepatitis, drug induced liver injury, liver cancer and other liver diseases, the liver’s ability to deal with indirect bilirubin is weakened, resulting in high indirect bilirubin and total bilirubin, and should be treated with liver diseases, bisabolol, glutathione and other liver-protecting treatments, as well as the treatment of the cause of the disease, for example, viral hepatitis can be applied to entecavir, and liver cancer can be treated with surgery. Total bilirubin 60umol/L indirect bilirubin 50umol/L should be timely to the hospital, under the guidance of the doctor to identify the causes and treatment.