Splenomegaly is commonly caused by the following reasons: 1) Physiological splenomegaly, some patients are born with a larger spleen than normal, which is not a cause for concern and can be followed up regularly. 2) Liver diseases, such as cirrhosis, ascites, or malignant tumors of the liver, because when the liver disease is more serious, it can lead to a slow return of the blood, resulting in an enlarged spleen. It may also be caused by hypersplenism, such as primary hypersplenism and secondary hypersplenism, in which the cause of primary hypersplenism is unknown and accompanied by hematopenia, which can be further investigated by abdominal enhanced CT, etc. 3. It may be caused by splenic abscess, which is due to serious infection of the spleen, and is manifested by obvious pain in the splenic area, which may be accompanied by tenderness and pain, and obvious elevation of leukocytes and neutrophils. 4. Elevation of white blood cells and neutrophils. 4. There is also the possibility of hypersplenism and enlargement of the spleen due to hemolytic anemia. In conclusion, if the spleen is enlarged, the cause needs to be further clarified for treatment.