Since cerebral palsy is a syndrome that can be caused by a variety of etiologies, pathological changes are associated with the etiology. Various congenital causes of cerebral developmental disorders are often seen as diffuse brain lesions with varying degrees of cerebral atrophy, enlarged ventricles, reduced neuronal cells, and glial cell hyperplasia. The pathological changes vary due to the length of the disease. In preterm infants, ischemic hypoxic encephalopathy can cause subventricular hemorrhage, softening of the white matter of the ventricles, which in turn liquefies to form multiple small foci of softening, which are absorbed in the form of small holes, and expansion of the softened area can form a cavity, called cerebral perforation malformation (or foramen ovale). Ischemic hypoxic encephalopathy in full-term infants can cause embolic-like changes. Brain necrosis is mostly seen in the deep cortical layers or in the white matter, gradually forming scarred brain gyrus, or it can soften to form cystic changes. The pathological changes of cerebral palsy can also be seen in myelin dysplasia, and the neurofibrillary tissue of the internal capsule is often involved. The clinical manifestations of the lesions vary depending on the location of the lesion.