Antinuclear Antibody Profile 17s is a group of autoantibodies that can detect cell nuclear components as target antigens, including anti-Smith antibody, anti-double-stranded DNA antibody, anti-Scl-70 antibody, anti-SS-B antibody and so on, which can be used to assist in the diagnosis of autoimmune diseases. Different items in Antinuclear Antibody Profile 17s can indicate different autoimmune diseases, for example, anti-Smith antibody and anti-double-stranded DNA antibody results are needed for systemic lupus erythematosus, anti-Scl-70 antibody results are needed for systemic sclerosis, and anti-SS-B antibody results are needed for desiccation syndrome. Antinuclear antibody profile 17s can detect autoantibodies produced against self-cellular components, but the diagnosis of related diseases does not rely solely on the results of antinuclear antibody profile 17s, but requires a combination of clinical manifestations and multiple test results to confirm the diagnosis. It is recommended that patients seek medical attention if necessary, and follow the doctor’s instructions for a definitive diagnosis.