It is possible that menstruation will return to normal after insulin resistance has cleared up, but it is not absolute, and other diseases that cause menstrual abnormalities need to be ruled out. Insulin resistance not only affects blood glucose, but several systems in the body are affected to varying degrees. If it affects estrogen and progesterone levels, female patients may exhibit menstrual disorders. If insulin resistance is more obvious, it may cause estrogen and progesterone secretion disorders, which may lead to menstrual irregularities, either heavy or light menstruation, or in severe cases, amenorrhea, which may lead to infertility. After the insulin resistance gets better, menstruation may return to normal. However, other diseases that cause abnormal menstruation, such as polycystic ovary syndrome and Cushing’s syndrome, need to be ruled out. Patients with insulin resistance who have abnormal menstruation are advised to seek prompt medical treatment.