Generalized joint pain and fever is generally rheumatic fever, bone tumors, colds, brucellosis and other causes, for the cause of the drug treatment. 1. Rheumatic fever: caused by streptococcal infection, through the laboratory anti-streptococcal O clear diagnosis, according to the cause of the application of erythromycin, penicillin drug treatment, the application of non-steroidal anti-inflammatory drugs such as aspirin or acetaminophen. 2. Bone tumor: apply painkillers, such as aminophenetidine tablets, for generalized joint pain caused by bone metastasis, and choose radiation therapy and chemotherapy according to the nature of the tumor. 2. Common cold: apply compound aminophenolamine or ribavirin granules, drink more water and pay attention to rest. 4. brucellosis: apply doxycycline or streptomycin treatment. Generalized joint pain and fever go to the hospital to identify the cause of the disease for treatment. The above medication should be administered under the guidance of a doctor.