There is no specific concept of how long a person can live with monoclonal immunoglobulinemia, and it may be related to the severity of the condition and the patient’s physical condition, and the exact time varies from person to person. Generally speaking, if the patient’s condition is not particularly serious, then there is no need for special treatment for the time being, as long as the patient goes to the hospital for regular check-ups, his/her life expectancy is generally unlikely to be affected. However, if the patient’s condition is serious and there are problems such as bone pain, anemia, infection, etc., then chemotherapy is needed under the guidance of the doctor, and commonly used drugs include thalidomide, vincristine, and so on. After a period of treatment, the survival time of patients will be relatively longer, and it can reach about 15 to 20 years. However, if the patient does not have timely treatment, leading to the deterioration of the disease and the development of multiple myeloma or macroglobulinemia, then life expectancy may be affected. Therefore, patients should try to standardize their treatment. In addition to actively cooperating with the doctor’s treatment, patients should adopt healthy living and dietary habits and maintain a good state of mind in general, so as to prolong their life expectancy.