Positive anti-glomerular basement membrane antibody is mostly manifested as acute progressive glomerulonephritis, and plasma exchange therapy is preferred for treatment, and methylprednisolone and cyclophosphamide shock therapy can also be considered. Anti-glomerular basement membrane antibody positive clinical manifestations of acute glomerulonephritis, also known as acute glomerulonephritis type I. Anti-glomerular basement membrane antibody mainly attacks two major organs, i.e. lungs and kidneys, so the patients mostly specifically manifest lung damage (coughing, coughing up sputum, blood in sputum or even hemoptysis, etc.) or kidney damage (oliguria, hematuria, proteinuria, abnormal renal function, etc.). The treatment for patients with positive anti-glomerular basement membrane antibody is mainly plasma exchange therapy, which can lower the antibody titer or even clear it to normal, so that the disease can be controlled to a certain extent. Plasma exchange usually involves the exchange of two to four liters of plasma at a time. Regarding the frequency of plasma exchange, it is recommended to stop plasma exchange after the anti-glomerular basement membrane antibody has become negative, which may require 10 times or even more than 10 times. Patients with positive anti-glomerular basement membrane antibodies may also consider shock therapy with methylprednisolone and cyclophosphamide, which can help relieve symptoms. Antiglomerular basement membrane antibody-positive patients should seek prompt medical attention, and the specific treatment plan should be in accordance with the doctor’s instructions.