Soreness in the arm after HPV injection, this condition occurs because after the HPV vaccine is injected, the vaccine components as well as the solutes in it cause an inflammatory reaction within the subcutaneous tissues of the arm, causing infiltration of inflammatory cells and leading to secretion of inflammatory mediators that irritate the surrounding nerves. Usually no treatment is needed, and it may be significantly relieved after about 2-3 weeks. However, individuals who have this condition for a longer period of time can use non-steroidal anti-inflammatory drugs, such as ibuprofen or diclofenac sodium which can help to relieve the pain and reduce the local inflammation. However, if it is accompanied by redness, swelling or pus secretion of the arm, it is necessary to go to the hospital for further examination.