Glucocorticoid medication can be used if the buttock rash is caused by eczema, antifungal medication should be used if it is caused by ringworm, and prickly heat powder should be used if it is caused by prickly heat. 1. Eczema: Eczema on the buttocks can be manifested as a red rash, and glucocorticoid creams such as hydrocortisone cream should be used, or glycerite lotion can be used. When itching is obvious, antihistamine drugs such as loratadine can be taken orally. 2. Ringworm: If there is a fungal infection, antifungal drugs such as ketoconazole cream should be used. If the external drug is not effective, oral itraconazole and other antifungal drugs should be taken. Usually, attention should be paid to keep the skin clean and dry, and use boiling water to sterilize clothes. 3. Prickly heat: If you sweat a lot, prickly heat phenomenon can occur, you can use prickly heat powder, glycerite lotion and so on to relieve. Keep the environment ventilated and wear loose and comfortable clothes. If the rash on the buttocks is obvious, you should go to the hospital and follow the doctor’s instructions when using medication.