Treatment of immunoglobulins
Immunoglobulins (including IgE, IgM, IgA, IgD, IgG) are antibodies produced by B cells. IgG can be found in all tissues and plasma. it is the most sufficient immunoglobulin and is an antibody to viruses and bacteria. Since 1981, IVIg has been used in patients suffering from viral infections, immunodeficiency diseases, and autoimmune disorders to regulate their immune response and restore their immunoglobulin levels to normal. IVIg is extracted from the blood of up to 50,000+ healthy donors. After washing and processing to remove red blood cells, the remaining serotonin and IgH antibody binding is used as a cover for hepatitis and HIV infection. The serotonin is injected through a droplet into the uppermost intravenous catheter of the hand.
IvgI fills the blood with good antibodies to fight those harmful effects, thus helping to protect the embryo and fetus from infection. It also assists in controlling the T cells, which are the producers of Th1 cellular activators and the resisters of NK cells, which are the th1:th2 balance converted into the th2 form that favors the child. Moreover, IvgI also helps to suppress B cells that would produce antibodies associated with low reproduction.
The first, second, third, and fifth
1, the tissue of the couple is too consistent ;
2, blood clotting question ;
3, immune counter to the baby.
5, leukocyte rampage) of immune problems in patients needing prescriptions, especially when.
1, NK cell-activated cytotoxin 50:1 exceeds 15%
2. CD56NK cell activation number exceeds 12% 3. TH1:TH2 and TNF motif ratio exceeds 30% (20 in some cases)
4. CD19+/5+ more than 10% of the total number of B cells
5. Low levels of block antibodies (determined by LAD test)
6, High ANA titers
7, Positive anti-thyroid antibody test
8, Impaired endometrial growth and immunopathology related
9, low amniotic fluid and immunopathology related
10.Patients experience massive subchorionic hemorrhage or hematoma
10, Patients have frequent autoimmune disorders
11. APAs do not respond to treatment with hepain, corticosteroids, and low doses of aspirin
12. Patients have antibodies to cholamines and serotonin
13.Replacement of steroid therapy is necessary
14, Implantation failure still occurs after treatment
15, Currently, the most consistently effective treatment is to reduce the number of NK cells and IVIg activity
The general dose of IVIg is 400 mg per kg of body weight, with a low dose determined by the number of NK cells, the level of active cytokines, the weight and other factors. A qualified nurse must be able to administer these injections, which generally last for 3 hours. Before the first treatment, the patient’s IgA level must be tested. In rare cases where IgA levels are low, IVIg is less useful because it can cause kidney damage from shock.
During the first phase of injections, an antihistamine product such as Benadry is used to reduce the chance of an allergic reaction.
During the pregnancy cycle, one or more treatments are necessary, depending on the severity of the patient’s immune problems. Because the effect of IVIg is short-lived, this procedure will have to be repeated every 10-21 days during pregnancy.
NK cell assays and TH1:TH2 assays are done within 7 to 10 days after each injection. Within three to four weeks of having both results, treatment can be stopped, although testing still continues every month. This is because 15% of women can activate NK cells after 24 weeks and then receive further injections.
Side effects
IVIg can be tolerated, although some patients experience headaches, tremors and bird flu symptoms. These side effects are largely short-term and are associated with the injections. When the rate decreases, the symptoms settle down. Subsequent injections are generally tolerated.
These preparations can be safely administered during pregnancy; as Dr. Beer has shown, IVIg is safe and life-protective for the child, and is acceptable for newborns with weak immune systems. Of course, there is also a restarting effect on the immune system, as those who receive it have fevers, craziness, and more controlled injections than they did before receiving the treatment. These protective antibodies are retained in circulation for one month. Side effects of intravenous human gammaglobulin.
1. IVIG is expensive. Because it is extracted from human blood, it is a blood product and, therefore, has the potential to transmit diseases. For example: hepatitis, syphilis, HIV, etc.
2.Very few patients may have transient headache, panic, nausea and other adverse reactions during the infusion, which may be related to the fast infusion rate or individual differences. Most of the above reactions are mild and often occur within one hour of the start of the infusion, so it is recommended to regularly observe the general condition and vital characteristics of the patient during the whole process of infusion, to slow down or suspend the infusion, which generally requires more than one can recover on its own without special treatment. Individual patients can have the above reaction after the end of infusion, and generally recover on their own within 24 hours.
3, IgA deficiency patients, after the infusion of IVIG can produce IgA antibodies, re-entry of IVIG when the class produced allergic reactions, a few occurred hemolysis, so IgA deficiency patients are prohibited.
4. IVIG treatment for patients with a history of migraine is likely to induce headache attacks and aseptic meningitis.
5, IVIG contains stabilizers such as sucrose, which can easily cause renal tubular necrosis and renal failure, so during IVIG treatment, attention should be paid to checking renal function.
6, the infusion process of Chinese medicine drink more water. Urinate more.
Side effects of intravenous injection of human gammaglobulin.
1, IVIG is expensive. Because it is extracted from human blood, it is a blood product, therefore, there is a possibility of infectious diseases. For example: hepatitis, syphilis, HIV, etc.
2.Very few patients may have transient headache, panic, nausea and other adverse reactions during the infusion, which may be related to the fast infusion rate or individual differences. Most of the above reactions are mild and often occur within one hour of the start of the infusion, so it is recommended to regularly observe the general condition and vital characteristics of the patient during the whole process of infusion, to slow down or suspend the infusion, which generally requires more than one can recover on its own without special treatment. Individual patients can have the above reaction after the end of infusion, and generally recover on their own within 24 hours.
3, IgA deficiency patients, after the infusion of IVIG can produce IgA antibodies, re-entry of IVIG when the class produced allergic reactions, a few occurred hemolysis, so IgA deficiency patients are prohibited.
4. IVIG treatment for patients with a history of migraine is likely to induce headache attacks and aseptic meningitis.
5, IVIG contains stabilizers such as sucrose, which can easily cause renal tubular necrosis and renal failure, so during IVIG treatment, attention should be paid to checking renal function.
6, the infusion process of Chinese medicine drink more water. Urinate more.